Megamind is one of the Blind Bag characters in Lego Dimensions 2: The Rise of Enoch, from the Megamind franchise.
Megamind (his birth name remains unknown) was born to an unnamed couple on his home planet. Eight days after Megamind's birth, the planet was detroyed by a black hole but he was able to survive thanks to his parents, who packed him in a escape pod with Minion and his binky and sent him off the planet. This makes Megamind and Minion the sole survivors of their planet.
On his way to Earth, he met an infant Metro Man, who was sent off of a neighbouring planet in a golden and better built escape pod. The infant Metro Man blew a raspberry at Megamind after the latter got out of an asteroid belt his pod got trapped in. With that, Megamind and Metro Man's "glorious rivalry" was born.
Megamind crash lands in the Prison for the Criminally Gifted at Metro City due to Metro Man's pod knocking his own away from the Scott Manor. Megamind is forced to grow up with criminals, who taught him to view cops as the bad guys and prisoners as the good ones (via flash cards). At some point in his childhood he was allowed to go to a normal school, were he became a neglected outcast due to his destructive intellect, with his piranha-like sidekick Minion as his only friend. Realizing that he is only gifted in causing trouble, and jealous of all of the attention and praise young Metro Man received, Megamind became a supervillain to rival Metro Man, though he was thwarted on a regular basis.
During one of his many attempts to defeat Metro Man, Megamind kidnaps news reporter Roxanne Ritchi and uses her as bait to lure Metro Man into the city observatory where Megamind intends to kill him with a death ray. When Metro Man is then seemingly killed by the death-ray, Megamind is initially thrilled that he has defeated his archenemy, and he proceeds to live the criminal dream life, taking over town hall and plundering the city. However, he soon grows depressed over the fact that without someone to fight, his life as a supervillain no longer has any purpose.
Megamind runs into a museum curator named Bernard while destroying the Metro Man Museum and, trying to avoid Roxanne, disguises himself as him, dehydrating and pocketing the real Bernard. Roxanne inadvertently inspires him to create a new superhero to fight, which he does using a serum of Metro Man's DNA. Hoping to uncover any evil plans Megamind has for the city, Roxanne breaks into Megamind's lairand fights with him over a syringe gun containing the serum, which is accidentally fired and injected into Roxanne's cameraman Hal StewartMegamind manipulates Hal into becoming a superhero named Titan under the guise of being his "space dad", but at the same time falls in love with Roxanne and begins dating her while disguised as Bernard, even sharing some of his own past (although still disguised) with her.
Megamind soon begins having second thoughts about being a villain, finding more enjoyment pursuing a relationship with Roxanne. Minion discovers this relationship and, worrying for his master's safety, quarrels with Megamind over it, claiming that "the bad guy doesn't get the girl!". Frustrated, Megamind claims that he doesn't want to be the bad guy anymore. He tells Minion to go and that he doesn't need him, causing their long friendship to appear irreparably lost.
After Roxanne kisses "Bernard" on a date, Megamind's identity is accidentally exposed, causing Roxanne (who cannot reconcile his true emotional nature with his past evil deeds) to reject him. Heartbroken, Megamind follows through with his plan to fight Tighten. He prepares a large battle mech, puts on an elaborate cape (torn up in Megamind: The Series), -called "The Black Mamba"- Minion made for him before their quarrel, and makes a grand appearance in the town plaza. He ends up spending most of the day there waiting for Tighten to show up, before going to his apartment. By this time, Tighten has decided he would rather be a supervillain. Disgusted, Megamind provokes Tighten by revealing he is both the "space dad" and Bernard. Utterly furious at the fact that Megamind was the "intellectual dweeb" who got Roxanne's affections, Hal attacks with a vengeance, however unlike Metro Man, has no qualms with outright killing Megamind, and Megamind is forced to flee for his life.
During the battle, Megamind attacks Tighten with a copper sphere, but is shocked to see Tighten escape it with ease. Confused and shocked about this inconsistency, Megamind convinces Roxanne to search for clues about his weaknesses in Metro Man's old hideout-which turns out to be the school where both Metro Man and Megamind went as children. There, they discover that Metro Man is still alive and learn that he faked his death (and his weakness to copper) so that he could retire from being a superhero.
Megamind and Roxanne try to persuade Metro Man to defeat Tighten, but he refuses. Roxanne and Metro Man instead prompt Megamind to fight, but he refuses, still believing himself unworthy of assuming the hero role, and leaves to turn himself in to the prison that was his home since childhood. However, when Tighten kidnaps Roxanne, Megamind appeals to the warden to let him go to save her. When the warden adamantly refuses, Megamind acknowledges his distrust but pleads for the chance to spare Roxanne from his enemy's hate. The warden, in a suprise twist, reveals himself to be Minion, who has returned to support his friend upon seeing his true nature. The two set off for the final battle.
Minion (disguised as Megamind) rescues Roxanne but breaks his fish bowl head in the process. Metro Man then miraculously shows up, but is actually Megamind in disguise. He manages to intimidate Tighten into fleeing the city, until he accidentally calls Metro City "Metrocity" (Megamind mispronounces simple words as he has no real contact with the outside world). After a beating from Tighten and getting flung into the air with the Defuser Gun (apparently to his death) which leads back to the first scene, Megamind defeats him by using his Dehydration gun to safely land in a fountain in Metro City's main square, and uses the Defuser Gun to remove Hal's unearned powers just before he can incinerate Roxanne. Minion is almost killed, but is saved when Megamind places him in the fountain. Hal ends up in Megamind's former prison cell, while Megamind is embraced by Metro City as its new defender. Roxanne accepts Megamind. Megamind decides he is deeply satisfied with his new role as the hero and Roxanne's beau, as a disguised Metro Man silently congratulates him