Clayface is one of the non-playable characters in LEGO Dimensions 2: The Rise of Enoch, from the DC Comics franchise.
Basil Karlo was an actor who became insane when he learned that a remake of a movie he starred in, The Terror, was in the works, even though he was a member of the advising staff. Karlo went on a murder spree dressed as the movie's villain, Clayface, and kills most of the remake's cast and crew, saving the actor in his old role for last, but Batman and Robin intervened.
After several other schemes, Karlo was visited by Sondra Fuller, the fourth Clayface. Karlo suggested that he, Fuller, and the other living Clayfaces of Preston Payne and Matt Hagen form the "Mud Pack" and attempt to kill Batman. The "Mud Pack" failed, but was able to transfer the powers of Fuller and Preston Payne (the third Clayface) into himself, which transforms himself into an actual Clayface (rather than dressing up as one).